Hepatitis b plant drugs, scientists identified a variety of compounds inhibiting HBVDNA replication as possible steps

2022-05-01 0 By

Recently, scientists have published some plant drugs targeting HBVDNA replication in authoritative journals, which have aroused great interest among readers. In this case, we will give a detailed description of the remaining 4 plant drugs that have the potential to inhibit HBVDNA introduced by scientists in the previous chapter.Picture 11. “?Hepatitis b plant drugs. Scientists identified a variety of compounds that inhibit HBVDNA replication as possible steps to develop plant drugs derived from current therapies such as nucleoside drugs (NUC), which usually require long-term or even lifelong administration. Drug resistance may occur after long-term use of NUC.Scientists have been searching for alternative drugs for resistant HBV.Over the years, various plant drugs and phytochemicals have been screened for potential anti-HBV effects in various cell culture systems (in vitro) and in mice or ducklings (in vivo) because of their superior safety, with early studies finding that they have virtually no side effects.Figure 7. Chemical structure of some xanthone compounds affecting HBV DNA replication xanthone compounds.Xanthanone is a cyclic oxidizing compound with a variety of bioactive properties, including antibacterial, antituberculous, antitumor, antiviral and antioxidant properties.Their health-boosting effects are largely due to their three-ring scaffolds.Xanthones, extracted from turmeric, showed inhibition during the advanced stages of HBV infection, the researchers found.Tocophenone compounds.Tocophenone is a seven-membered aromatic ring compound consisting of a cyclic ketone functional group (cyclohepta-2,4, 6-triene-1-1-2 replaced by an hydroxyl group).It is a toxin produced by the agricultural pathogen burkholderia and is an antibacterial and antifungal compound.Figure 8. Chemical structure of some of the tocophenone compounds affecting HBV DNA replication polysaccharide compounds.Polysaccharides are natural polymers found in plants in the form of starch or cellulose.Recent studies on polysaccharides have shown that they exhibit a wide range of biological activities, including immune-enhancing, antiviral and anti-inflammatory effects, and anti-HBV effects.Figure 9. Chemical structure of polysaccharide compounds affecting HBVDNA replication other plant compounds.Some compounds that do not fall into these categories have also been reported to reduce HBVDNA replication.Coumarin is distributed in a variety of plant species. In HepG2.2.15 cells and ducklings infected with DHBV, we evaluated its anti-HBV effect and showed that HBVDNA was significantly reduced in coumarin-treated cells and ducklings compared to the control group!Cananga odorata, an Indonesian plant, reduced HBV DNA and HBsAg secretion in Hep38.7-TET cells with IC50 of 56.5 μg/mL.FIG. 10 chemical structure of other Compounds affecting HBVDNA replication Most previous studies focusing on screening plants and phytochemicals for down-regulation of HBV replication have only made preliminary progress, and several studies have demonstrated anti-HBV effects of total plant extracts, according to researchers.However, the mechanism and structure of these plant compounds affecting HBV replication have not been determined in the past.Most previous studies have been conducted using in vitro systems, such as transient transfection of hepatocellular carcinoma cells with HBV replication-capable plasmids or stable HBV-producing HepG2.2.15 cells.Only a few studies were conducted using in vivo models, such as Beijing DHBV ducklings or transgenic mice.An important limitation of these studies is that none of them elucidate the exact mechanisms by which screening plant drugs and phytochemicals inhibit HBVDNA replication.The HBV replication process is very complex and has several steps.Some important steps in HBVDNA replication and virion production include production of cccDNA from partial dsDNA, transcription of cccDNA template leading to four RNA strands, pgRNA encapsulation, intracapsid reverse transcription, synthesis of (+) strands intracapsid DNA, assembly of surface proteins, and virion release.Conclusion: Let’s briefly review the scientific research opinions of researchers from the Department of Microbiology and Health of Agricultural University of Bangladesh and the Department of Life Sciences of Graduate School of Osaka University in Japan.These phytochemicals have shown potential safety benefits as an alternative to existing anti-HBV therapies. In the past, these phytochemicals have only been found to inhibit HBV replication, but the exact mechanism by which the virus is inhibited has not been thoroughly explored.In this study, the researchers observed that the plant compounds described above can interfere with any step of HBVDNA replication and virion production, possibly reducing DNA levels and virion copy number.The mechanisms by which these phytodrugs and phytochemicals affect HBV-derived factors and signaling pathways as well as the host immune system remain to be studied.